Patient-Specific Haemodynamic Modeling to Estimate the Extent of Microvascular Disease and Response to Pulmonary Endarterectomy in Chronic Thromboembolic Pulmonary Hypertension

Shaarbaf Ebrahimi, B., Khwaounjoo, P., Chan, H., Argus, F., Ma, X., Nash, M. P., Doi, A., Dagan, M., Kaye, D. M., Joseph, T., McGiffin, D., Tawhai, M. H. Pulmonary Circulation DOI: 10.1002/pul2.70176

Abstract: Chronic thromboembolic pulmonary hypertension (CTEPH) is a form of pulmonary hypertension that is caused by persistent obstruction of the pulmonary arteries by organized thrombi and associated microvascular disease. Pulmonary endarterectomy (PEA) is the gold standard treatment, but the extent of small vessel remodeling, which strongly influences treatment outcomes, remains difficult to quantify pre-operatively. We developed a multiscale, structure-based model of the pulmonary circulation using patient-specific vascular geometries from CT pulmonary angiography (CTPA) and haemodynamic data from right heart catheterization (RHC).