The intensive care medicine research agenda for the management of ICU acquired weakness

Eggmann, S., Parry, S. M., Broadley, T., Lynch, G. S., Bongetti, A. J., Ridley, E. J., Ayre, E., Bailey, M., Bellomo, R., Berney, S., Bradley, S., Buhr, H., Campbell, M. K., Casey, K., Chapple, L. S., Connolly, B., Darvall, J., Deane, A., Febbraio, M. A., Gosselink, R., Granger, C. L., Haines, K., Hanekom, S., Harhay, M. O., Harrold, M., Hayes, K., Hermans, G., Higgins, A., Jain, S., Kho, M. E., Tirupakuzhi Vijayaraghavan, B. K., Lambell, K., Lang, J. K., Leditschke, I. A., Levinger, I., Magana Cruz, S., Marshall, A. P., Needham, D. M., Ntoumenopoulos, G., Nydahl, P., Patel, B. K., Paton, M., Puthucheary, Z., Rooyackers, O., Schaller, S. J., Serpa Neto, A., Stoppe, C., Tronstad, O., Vanhorebeek, I., Z’Graggen, W. J., Hodgson, C. L.

Intensive Care Medicine DOI: 10.1007/s00134-025-08186-4

Abstract: Intensive care unit acquired weakness (ICUAW) is common in critically ill patients, contributing to substantial morbidity. Major trials and novel mechanistic findings published over the past years have advanced knowledge for the prevention and treatment of ICUAW. To streamline future research priorities, a multinational, interdisciplinary group of ICU clinicians, researchers, and people with lived experience convened to develop this evidence-based research agenda.