Pulmonary Hypertension Under the Microscope

Dagan, M., Nanayakkara, S., Chan, W., Beale, A., Yo, S., McGiffin, D. C., Kaye, D. M., CHEST, 10.1016/j.chest.2026.07.5215

Abstract: Pulmonary hypertension comprises a heterogeneous group of conditions characterised by elevated mean pulmonary artery pressure and classified into five groups according to underlying aetiology. Across PH subtypes, pathological remodelling of the pulmonary microvasculature, including arterioles, capillaries, and venules, drives hemodynamic burden, right ventricular dysfunction, and clinical outcomes. While certain structural features are conserved, distinct histopathological patterns shape group-specific pathophysiology, treatment responses, and prognosis.