An Integrated Clinical-Histopathologic Prediction Model for Cardiac Allograft Rejection

Written By CCRG

Kim, D., Madabhushi, A., Margulies, K., Peyster, E. Journal of Heart and Lung Transplantation DOI: 10.1016/j.healun.2026.04.031

Abstract: Cardiac allograft rejection (CAR) remains the leading cause of early graft failure after heart transplantation (HT). Current diagnostics, including histologic grading of endomyocardial biopsy (EMB) and blood-based assays, lack accurate predictive power for future CAR risk. We developed a predictive model integrating routine clinical data with EMB-derived quantitative morphologic features to demonstrate the precision-medicine potential of mining existing data sources in post-HT care.

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