Preserving the future of heart transplantation

Kaye, D. M., & McGiffin, D. C. Nature Reviews Cardiology DOI: 10.1038/s41569-025-01146-x

Abstract: Heart transplantation remains the optimal long-term treatment for appropriate patients with advanced heart failure. However, the donor heart shortage is a limiting factor, and the risk profile of transplant candidates is worsening. In this landscape, the utility of conventional cold static storage for donor hearts is increasingly limited. In this Clinical Outlook, we discuss new methods of donor heart preservation that are transforming the future of heart transplantation.

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