Cell-free mitochondrial DNA may predict the risk of post-operative complications and outcomes in surgical aortic valve replacement patients

Hyslop K, Ki KK, Naidoo R, O'Brien D, Prabhu A, Gill D, Anstey C, Rapchuk IL, McDonald CI, Marshall L, Pearse I, Fraser JF, Suen JY, Passmore MR. Scientific Reports DOI: 10.1038/s41598-025-00382-y

Abstract: Surgical aortic valve replacement (AVR) is the standard of care for severe aortic valve disease; however, post-operative complications continue to pose challenges. Inflammation caused by increased release of cell-free mitochondrial DNA (cf-mtDNA) during surgery may be a contributing factor. The aim of this pilot study was to investigate the relationship between cf-mtDNA release and the risk of inflammatory-mediated post-operative complications in adult AVR patients.