Early differential protein expression in blood and bronchoalveolar fluid among ARDS phenotypes

Wildi, K., Bihari, S., Bersten, A., Dixon, D., Paul, E., McGuinness, S., Hodgson, C., Nichol, A., Chataway, T., Colella, A., Gebhard, C., Chegeni, N., Matigian, N., LiBassi, G., Passmore, M., Bouquet, M., Ritchie, A., Suen, J., Fraser, J. Scientific Reports DOI: 10.1038/s41598-026-43956-0

Abstract: Protein pathways underlying ARDS phenotypes are not fully elucidated. The aim of this subanalysis of an international randomized controlled clinical trial, which assessed the potential benefit of a maximal lung recruitment strategy, was to identify protein signatures in serum and bronchoalveolar fluid associated with ARDS phenotypes and to improve understanding of the underlying biological pathways.