The development of a high-plex spatial proteomic methodology for the characterisation of the head and neck tumour microenvironment

Tan, C., Berrell, N., Donovan, M., Monkman, J., Sadeghirad, H., Naei, V., Chen, J., Rossenbloom, A., Bonnett, S., Conner, M., Filanoski, B., Kang, C., Beechem, J., Fraser, J., Barnett, C., Ladwa, R., Hughes, B., Kulasinghe, A. npj Precision Oncology DOI: 10.1038/s41698-025-00963-0

Abstract: Head and neck squamous cell carcinoma (HNSCC) is a debilitating disease that accounts for an estimated 890,000 new cases per year. Despite advancements in chemotherapy, radiotherapy, surgery and immunotherapy, the prognosis of HNSCC has remained relatively unchanged for more than a decade. Insight into the tumour microenvironment (TME) using spatially resolved approaches, and its association with clinical endpoints, may provide useful prognostic tools and refine current treatment outcomes.