Vasopressors or Fluids in Early Septic Shock

Peake, S. L., Macdonald, S. P. J., Howe, B. D., Milford, E., Jones, P., Arendts, G., Bailey, M., Burcham, J., Delaney, A., Egerton-Warburton, D., Fatovich, D., Fraser, J., Higgins, A. M., Keijzers, G., Udy, A. A., Williams, P., Young, P. J., Bellomo, R. The New England Journal of Medicine DOI: 10.1056/NEJMoa2516225

Abstract: The optimal approach to early resuscitation in septic shock is unknown. Equipoise exists between the use of larger volumes of intravenous fluids to restore perfusion and the use of early vasopressor therapy along with smaller volumes of fluids to minimize potential harm from excess fluid.