Using biofilm-targeting local antibiotics to treat recalcitrant medical device–associated infections

Qu, Y., Kaye, D. M., McGiffin, D., Peleg, A. Y. Journal of Antimicrobial Chemotherapy DOI: 10.1093/jac/dkag203

Abstract: Driveline infection, exemplifying medical device–associated infection, is a difficult-to-treat complication of ventricular assist device implantation in which biofilm formation underlies both infection onset and recurrence. Although clinical experience remains limited, treatment success has been reported in cases where local antibiotics at high concentrations were used in combination with surgical debridement and/or device reimplantation.