SM3DD with segmented PCA

Blick, T., Kilgallon, A., Monkman, J., Cooper, C., Tan, C., Killingbeck, E., Pan, L., Kim, Y., Liang, Y., Nam, A., Leon, M., Guimaraes, P., Nagashima, S., Martins, A., Machado-Souza, C., de Noronha, L., Fraser, J., Belz, G., Souza-Fonseca-Guimaraes, F., Kulasinghe, A. NAR Genomics and Bioinformatics. DOI: 10.1093/nargab/lqag007

Abstract: We developed Standardised Minimum 3D Distance (SM3DD), an entirely cell segmentation/annotation-free approach to the analysis of spatial RNA datasets, using it to compare lung tissue from 16 clinically normal individuals to that of 18 SARS-CoV-2 patients who died from acute respiratory distress syndrome.