Chan, C., Passmore, M., Tronstad, O., Seale, H., Bouquet, M., White, N., Teruya, J., Hogan, A., Platts, D., Chan, W., Dashwood, A., McGiffin, D., Maiorana, A., Hayward, C., Simmonds, M., Tansley, G., Suen, J., Fraser, J., Meyns, B., Fresiello, L., Jacobs, S. ASAIO Journal DOI: 10.1097/MAT.0000000000002246
Abstract: Impaired primary hemostasis and dysregulated angiogenesis, known as a two-hit hypothesis, are associated with gastrointestinal (GI) bleeding in patients with continuous-flow left ventricular assist devices (CF-LVADs). Exercise is known to influence hemostasis and angiogenesis in healthy individuals; however, little is known about the effect in patients with CF-LVADs. The objective of this prospective observational study was to determine whether acute exercise modulates two-hit hypothesis mediators associated with GI bleeding in patients with a CF-LVAD.