Animal models of critical care illnesses

Written By CCRG

Fraser, J. F., Inoue, S., Yao, Y., Osuchowski, M. F. Intensive Care Medicine Experimental DOI: 10.1186/s40635-025-00776-2

Abstract: Critical care medicine addresses multiple life-threatening conditions including sepsis, polytrauma, shock and acute respiratory distress syndrome (ARDS) as well as recent global threats like COVID-19. Advancing clinical improvements for patients suffering from these illnesses is contingent upon understanding of their complex pathophysiology, developing precise/rapid diagnostic tools and effective therapies. Animal models have long served as a cornerstone of this endeavor offering invaluable discoveries including first test of closed-chest cardiac massage technique in 1959 (developed in dogs) and first use of anti-SARS-CoV-2 vaccine in 2020 (tested in rodents and non-human primates).

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