Investigation of heparin-loaded poly(ethylene glycol)-based hydrogels as anti-thrombogenic surface coatings for ECMO

2022
Written By CCRG CCRG Admin

Meili Zhang, Chris H.H. Chan, Jo P. Pauls, Clayton Semenzin, Carmen Ainola, Hui Peng, Changkui Fu, Andrew K. Whittaker, Silver Heinsar and John F. Fraser.  Journal of Materials Chemistry DOI: 10.1039/D2TB00379A

Abstract: Extracorporeal membrane oxygenation (ECMO), a critical life-sustaining tool, faces significant challenges for the maintenance of normal haemostasis due to the large volume of circulating blood continuously in contact with artificial surfaces, hyperoxia and excessive shear stresses of the extracorporeal circuit. From a biomaterials perspective, it has been hypothesised that drug eluting coatings composed of haemocompatible hydrogels loaded with an anticoagulant drug could potentially enhance the haemocompatibility of the circuit.

CCRG CCRG Admin
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