Sex differences in post-acute neurological sequelae of SARS-CoV-2 and symptom resolution in adults after COVID-19 hospitalization

Written By CCRG

Sung-Min Cho, Lavienraj Premraj, Denise Battaglini, Jonathon Paul Fanning, Jacky Suen, Gianluigi Li Bassi, John Fraser, Chiara Robba, Matthew Griffee, Tom Solomon, Malcolm G Semple, Kenneth Baillie, Louise Sigfrid, Janet T Scott, Barbara Wanjiru Citarella, Laura Merson, Rakesh C Arora, Glenn Whitman, David Thomson, Nicole White, ISARIC Clinical Characterisation Group. DOI https://doi.org/10.1093/braincomms/fcae036

Abstract: Although it is known that COVID-19 can present with a range of neurological manifestations and in-hospital complications, sparse data exist if these initial neurological symptoms of COVID-19 are closely associated with post-acute neurological sequelae of SARS-CoV-2 (PANSC) and if female versus male sex impacts the symptom resolution. In this international, multicentre, prospective observational study across 407 sites from 15 countries (January/30th/2020-April/30th/2022), we report the prevalence and risk factors of PANSC among hospitalized adults and investigate the differences between males and females on neurological symptom resolution over time.

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