Transcriptomic profiling of cardiac tissues from SARS-CoV-2 patients identifies DNA damage

A Kulasinghe, N Liu, C W Tan, J Monkman, J E Sinclair, D D Bhuva, D Godbolt, L Pan, A Nam, H Sadeghirad, K Sato, G L Bassi, K O'Byrne, C Hartmann, A F R dos Santos Miggiolaro, G L Marques, L Z Moura, D Richard, M Adams, L de Noronha, C Pellegrino Baena, J Y Suen, R Arora, G T Belz, K R Short, M J Davis, F Souza-Fonseca Guimaraes, J F Fraser. Immunology DOI: doi.org/10.1111/imm.13577

Abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is known to present with pulmonary and extra-pulmonary organ complications. In comparison with the 2009 pandemic (pH1N1), SARS-CoV-2 infection is likely to lead to more severe disease, with multi-organ effects, including cardiovascular disease. SARS-CoV-2 has been associated with acute and long-term cardiovascular disease, but the molecular changes govern this remain unknown. To investigate the host transcriptome changes of cardiac tissues from patients who died from COVID-19, pH1N1, and healthy cardiac tissues.