Meet Dr Nchafatso Obonyo
Obonyo’s early interest in medicine
Dr Obonyo’s fascination with medicine started at a young age when he volunteered at hospitals and nursing homes as part of his education at the Alliance High School in his home country of Kenya. Here he was introduced to influential doctors and was inspired to learn more about how to help the sick.
The current treatment of septic shock
After receiving his medical degree from the University of Nairobi, Dr Obonyo took an internship at the Kijabe Mission Hospital on the outskirts of Nairobi.
As part of his paediatric rotation, Dr Obonyo cared for critically ill children who experienced septic shock from blood-borne infections. At the time the main treatment option for septic shock was intravenous fluid bolus, where a large volume of fluid is rapidly administered to try an improve a patient’s blood pressure. The outcomes however were not always optimal with many patients dying hours after initial improvement.
Re-examining current treatment guidelines
So in 2011, Dr Obonyo joined the KEMRI-Wellcome Trust Research programme to examine the supporting evidence for the septic shock treatment guidelines. Subsequently in 2013, he was awarded the prestigious Global Health Research Fellowship from the Wellcome Trusts Centre for Global Health Research at the Imperial College London for his work on the management of septic shock in critically ill children.
Dr Obonyo was recently invited to a reception to His Excellency Amb. John Tipis, High Commissioner for Kenya to discuss his research and future collaborations with his home country. The event was organised by Kenyans in Queensland, a networking group that promotes Kenyan culture and foreign exchanges across the state.
Dr Obonyo joined The Prince Charles Hospital’s Critical Care Research Group in 2014 and awarded a Research Fellowship and an Innovation Grant from The Common Good in 2021.
Above: Dr Obonyo with His Excellency Amb. John Tipis, High Commissioner for Kenya (left) and First Counsellor, Mr Mathew Kaikai (right). Bottom: Dr Obonyo (top row, third left) at the Kenyans in Queensland Reception, Brisbane, February 2022.
The potential benefit of reviewing septic shock treatments
With an estimated incidence of 49 million cases annually of sepsis and a 20% death rate in the developed world, this research has enormous implications for the health outcomes of millions of people. The continuation of this important research would not be possible without the support of The Common Good and their donors. When you support The Common Good, you are backing incredible, talented researchers like Dr Obonyo whose work will hopefully inform changes to how septic shock is treated, which could quite literally save millions of lives worldwide.
Read more about Dr Obonyo’s life-saving research here
Abbate G, Colombo SM, Semenzin C, Sato N, Liu K, Ainola C, Milani A, Fior G, Obonyo N, White N, Chiumello D, Pauls J, Suen JY, Fraser JF, Li Bassi G.
Silver Heinsar, Kei Sato, Nchafatso Obonyo, Samia M Farah, Mahe Bouquet, Margaret R Passmore, Keibun Liu, Shinichi Ijunin, Carmen Ainola, Gianluigi Li Bassi, Jacky Y Suen, and John Fraser.
Thomas O. Kirengo, Hussein Dossajee, Evans M. Onyango, Reema H. Rachakonda, Bailey Schneider, Declan P. Sela, Zahra Hosseinzadeh, Zohaib Nadeem & Nchafatso G. Obonyo
Obonyo NG, Sela DP, Raman S, Rachakonda R, Schneider B, Hoe LES, Fanning JP, Bassi GL, Maitland K, Suen JY, Fraser JF.
Sato K, Wildi K, Chan J, Palmieri C, Obonyo NG, Heinsar S, Liu K, Livingstone S, Sato N, Ainola C, Abbate G, Bouquet M, Wilson E, Passmore M, Hyslop K, Platts DG, Suen J, Bassi GL, Fraser JF.
Obonyo N.G.; Lu L.Y.; White N.M.; Sela D.P.; Rachakonda R.H.; Teo D.; Tunbridge M.; Sim B.; See Hoe L.E.; Fanning J.P.; Tung J.-P.; McKnoulty M.; Bassi G.L.; Suen J.Y.; Fraser J.F.
Malfertheiner MV, Garrett A, Passmore M, Haymet AB, Webb RI, Von Bahr V, Millar JE, Schneider BA, Obonyo NG, Black D, Bouquet M, Bartnikowski N, Suen JY, Fraser JF
Dhanapathy V, Obonyo N, White N, Sela D, Rachakonda R, Tunbridge M, Sim B, Teo D, Hoe LS, Fanning J, Tung J, Suen J, Fraser J
Sato K, Heinsar S, Obonyo N, Wildi K, Liu K, Farah S, Ainola C, Sato N, Ijuin S, Ro SK, Fior G, Gandini L, Bouquet M, Wilson E, Passmore M, Hyslop K, Chan J, Platts D, Scalia G, Suen J, Bassi GL, Fraser J
See Hoe LE, Li Bassi G, Wildi K, Passmore MR, Bouquet M, Sato K, Heinsar S, Ainola C, Bartnikowski N, Wilson ES, Hyslop K, Skeggs K, Obonyo NG, Shuker T, Bradbury L, Palmieri C, Engkilde-Pedersen S, McDonald C, Colombo SM, Wells MA, Reid JD, O'Neill H, Livingstone S, Abbate G, Haymet A, Jung JS, Sato N, James L, He T, White N, Redd MA, Millar JE, Malfertheiner MV, Molenaar P, Platts D, Chan J, Suen JY, McGiffin DC, Fraser JF.
Sun Kyun Ro, Kei Sato, Shinichi Ijuin, Declan Sela, Gabriele Fior, Silver Heinsar, Ji Young Kim, Jonathan Chan, Hideaki Nonaka, Aaron C. W. Lin, Gianluigi Li Bassi, David G. Platts, Nchafatso G. Obonyo, Jacky Y. Suen and John F. Fraser
Gandini L, Fior G, Schibler A, Obonyo N.G, Li Bassi G, Suen JY, Fraser JF
Kei Sato, Silver Heinsar, Karin Susanne Wildi, Nchafatso Obonyo, Keibun Liu, Samia Farah, Carmen Ainola, Noriko Sato, Gabriele Fior, Sun Kyun Ro, Lucia Gandini, Shinichi Ijuin, Mahe Bouquet, Emily Wilson, Margaret Passmore, Kieran Hyslop, Jonathan H. Chan, David Platts, Jacky Suen, Gianluigi Li Bassi, John Fraser
Fanning, Jonathon P., Weaver, Natasha, Fanning, Robert B., Griffee, Matthew J., Cho Sung-Min, Panigada, Mauro, Obonyo, Nchafatso G. Zaaqoq, Akram M.; Rando, Hannah; Chia, Yew Woon; Fan, Bingwen Eugene; Sela, Declan; Chiumello, Davide; Coppola, Silvia; Labib, Ahmed; Whitman, Glenn J. R.; Arora, Rakesh C.; Kim, Bo S.; Motos, Anna; Torres, Antoni; Barbé, Ferran; Grasselli, Giacomo; Zanella, Alberto; Etchill, Eric; Usman, Asad Ali MMD, MPH30; Feth, Maximilian; White, Nicole M.; Suen, Jacky Y.; Li Bassi, Gianluigi; Peek, Giles J.; Fraser, John F.; Dalton, Heidi on behalf of the COVID-19 Critical Care Consortium (COVID Critical)
Sato, Kei; Chan, Jonathan; Appadurai, Vinesh; Obonyo, Nchafatso; See Hoe, Louise; Suen, Jacky Y.; Fraser, John F.
Yu Peng-Ming, Wang Yu-Qiang, Luo Ze-Ruxing, Tsang Raymond C. C., Tronstad Oystein, Shi Jun, Guo Ying-Qiang, Jones Alice Y. M.
Kei Sato, Nicole White, Jonathon P. Fanning, Nchafatso Obonyo, Michael H. Yamashita, Vinesh Appadurai, Anna Ciullo, Meryta May, Elliott T. Worku, Leticia Helms, Shinichiro Ohshimo, Dafsah A. Juzar, Jacky Y. Suen, Gianluigi Li Bassi, John F. Fraser, Rakesh C. Arora on behalf of COVID-19 Critical Care Consortium Investigators
Walweel, K., Boon, A. C., See Hoe, L. E., Obonyo, N. G., Pedersen, S. E., Diab, S. D., Passmore, M. R., Hyslop, K., Colombo, S. M., Bartnikowski, N. J., Bouquet, M., Wells, M. A., Black, D. M., Pimenta, L. P., Stevenson, A. K., Bisht, K., Skeggs, K., Marshall, L., Prabhu, A., James, L. N., … Fraser, J. F. (2021). https://doi.org/10.1016/j.bj.2021.10.007
See Hoe, L.E., Wildi, K., Obonyo, N.G. et al. A clinically relevant sheep model of orthotopic heart transplantation 24 h after donor brainstem death. ICMx 9, 60 (2021).
Wells, M. A., et al. (2021). "Compromised right ventricular contractility in an ovine model of heart transplantation following 24 h donor brain stem death." Pharmacological Research 169: 12.