Pre-storage leucoreduction of platelet concentrates reduced biological response modifier concentrations and TRALI incidence in an in vivo sheep model

Tung, J., Simonova, G., Hewlett, E., Engkilde Pedersen, S., Esguerra Lallen, A., Alkhureeb, F., Wellburn, R., Chiaretti, S., Temple, F., Duong, T., Cinel, M., Giles, C., Meikle, P., Fraser, J. Scientific Reports DOI: 10.1038/s41598-025-26159-x

Abstract: Transfusion-related acute lung injury (TRALI) is a potentially fatal transfusion reaction. It can be caused by the transfusion of proteins, lipids, and extracellular vesicles that accumulate in blood components during routine storage and are collectively referred to as biological response modifiers (BRMs). It has been suggested that leucoreduction might reduce TRALI risk by limiting the accumulation of leucocyte-derived BRMs; however, there are conflicting data from haemovigilance reports and animal models regarding this.