High-flow Oxygen and Nitric Oxide inhalation versus high-flow oxygen alone to prevent intubation in hypoxaemic Respiratory failure (HONOR)

Churchill, L., Tronstad, O., Hay, K., Thomas, P. J., Shekar, K. Pilot and Feasibility Studies DOI: 10.1186/s40814-025-01726-1

Abstract: When conventional oxygen therapies fail, endotracheal intubation and invasive mechanical ventilation are the current standard of care in patients with acute hypoxaemic respiratory failure. However, invasive mechanical ventilation is associated with increased hospital and intensive care length of stay, healthcare costs, and morbidity and mortality. Inhaled nitric oxide has the potential to treat hypoxaemia and potentially prevent the need for invasive mechanical ventilation.