Cardiac Mitochondrial and Electrophysiological Changes in Transplanted Ovine Hearts Following Preservation by Hypothermic Oxygenated Perfusion

See Hoe, L.E., Bouquet, M., Bartnikowski, N., Wells, M.A., Devaux, J., Hyslop, K., Passmore, M.R., Wilson, E.S., Reid, J.D., O'Neill, H., Shuker, T., Obonyo, N.G., Sato, K., Heinsar, S., Wildi, K., Ainola, C., Abbate, G., Peart, J.N., Wendt, L., Engkilde-Pedersen, S., Parker, S.E., Lu, L., White, N., Molenaar, P., Li Bassi, G., Haqqani, H., McGiffin, D.C., Suen, J.Y., Fraser, J.F. Transplantation DOI: 10.1097/TP.0000000000005490

Abstract: During heart transplantation (HTx), donor hearts are exposed to injury via brain death (BD) and cardiac preservation using static cold storage (SCS). Preservation using hypothermic oxygenated machine perfusion (HOPE) may reduce myocardial injury compared with SCS preservation. This study sought to better understand how the BD donor cardiac allograft is modified before HTx and posttransplant following HOPE preservation.