Combined heart-lung transplantation

Hayes, D. Jr, Budev, M.M., McGiffin, D.C. Journal of Heart and Lung Transplantation DOI: 10.1016/j.healun.2025.07.003

Abstract: Combined heart-lung transplant (HLT) peaked globally in 1989–1990 with a subsequent fall in case numbers; however, there has been a steady increase in the number of HLTs performed in the United States since 2014. Due to rising interests in HLT, there was a timely session on HLT at the International Society for Heart and Lung Transplantation 45th Annual Meeting and Scientific Sessions. The session highlighted a novel approach to reduce geographical limitations for donor organs using ex vivo normothermic perfusion, but it re-introduced historical complications associated with en bloc double lung transplantation and the tracheal anastomosis.

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Cardiac Mitochondrial and Electrophysiological Changes in Transplanted Ovine Hearts Following Preservation by Hypothermic Oxygenated Perfusion