Open‑lung ventilation versus no ventilation during cardiopulmonary bypass in an innovative animal model of heart transplantation

Colombo, S. M., Karnik, V., Rickards, L., See Hoe, L., Wildi, K., Passmore, M., Suen, J., McGriffin, D., Fraser, J., Li Bassi, G. Critical Care DOI: 10.1186/s13054-024-04822-5

Abstract: Open-lung ventilation is a potential strategy to mitigate acute respiratory failure following cardiac surgical procedures with cardiopulmonary bypass (CPB), such as heart transplantation (HTx). We conducted a randomized study in an innovative ovine model of HTx to investigate whether open-lung ventilation during CPB reduces postoperative lung damage and complications