Animal models of critical illness in the Asia–Pacific region

Fujinami, Y., Liu, S., Li Bassi, G., Osuchowski, M., Yao, Y., Fraser, J., Inoue, S. Intensive Care Medicine Experimental DOI: 10.1186/s40635-026-00874-9

Abstract: Animal models of critical illness span diverse species and experimental approaches, reflecting the biological complexity of severe disease states while being constrained by animal welfare requirements and country-specific regulatory, infrastructural, and workforce factors. Persistent challenges remain, including limited reproducibility, fragmented standards, and the need for ethical alignment across borders. This review examines these shared structural challenges in critical illness animal research across the Asia–Pacific region.