Population pharmacokinetics of meropenem in critically ill adult patients receiving extracorporeal membrane oxygenation

Abdul-Aziz, M., Cheng, V., Burrows, F., Buscher, H., Cho, Y., Corley, A., Diehl, A., Gilder, E., Kim, H., Levkovich, B., Lim, S., Liu, X., McGuinness, S., Ordonez, J., Parke, R., Pellegrino, V., Reynolds, C., Rudham, S., Wallis, S., Welch, S., Fraser, J., Shekar, K., Roberts, J. Journal of Antimicrobial Chemotherapy DOI: 10.1093/jac/dkag090

Abstract: To describe meropenem population pharmacokinetics in critically ill adults receiving extracorporeal membrane oxygenation (ECMO) with or without renal replacement therapy (RRT), and to identify dosing regimens likely to achieve safe and effective exposures.